RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
CREB1
RNA ID
RNA Type
mRNA
Alteration Pattern
creb 1 phosphorylation
Species
homo sapiens
Detection Methods
RT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Post translational modification of creb-1 decreases collagen I expression by inhibiting the TGF B1 signaling pathway in rat hepatic stellate cells
Year
2016
Function
"The increase in opn induces hmgb1, which acts as a downstream alarmin driving collagen-i synthesis in hscs."